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M94A3178.TXT
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1994-10-25
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Document 3178
DOCN M94A3178
TI Rat model of HTLV-I infection--morphological study of HAM rat disease.
DT 9412
AU Abe M; Fukatsu R; Seto K; Tomaru U; Ohya O; Kasai T; Yamashita I; Ikeda
H; Wakisaka A; Yoshiki T; Dept. Pathol., Hokkaido Univ. Sch. Med.,
Japan.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):135 (abstract no. PA0160). Unique
Identifier : AIDSLINE ICA10/94369397
AB OBJECTIVE: To analyse mechanisms involved in the development of
HTLV-I-associated diseases, animal models have long been needed. Here we
show a rat model of HAM/TSP in humans, designated as HAM rat disease,
which develops a chronic progressive myelopathy associated with HTLV-I
infection after 16 months of incubation. METHODS: 1 x 10(7) cells of
MT-2, an immortalized human T lymphocyte cell line producing HTLV-I,
were inoculated into newborn or 16 week-old WKAH rats. They were
chronologically sacrificed and spinal cord and peripheral nerve tissues
were histologically and ultrastructurally examined. RESULTS: They showed
gait disturbance and hind leg paraparesis 16 months after infection.
Pathological alterations of HAM rat disease were mainly confined to
marginal areas of white matter of the spinal cord. Vacuolation,
macrophage infiltration, and demyelination were observed in the affected
lesion. We observed some apoptotic cell death of the oligodendrocytes
and Schwann cells with condensed nucleus and phagocytosis of apoptotic
bodies by macrophages. DISCUSSION AND CONCLUSIONS: Apoptosis of the
oligodendrocytes and Schwann cells mediated by HTLV-I infection may be
the primary cause of HAM rat disease, although the precise mechanism of
apoptosis is not known at present. This HAM rat disease model will aid
in investgating the pathogenesis of the demyelinating process of HAM/TSP
in humans and other retrovirus-induced central nervous diseases such as
HIV-induced vacuolar myelopathy.
DE Animal Apoptosis Cell Line, Transformed Disease Models, Animal Human
HTLV-I/GROWTH & DEVELOPMENT HTLV-I
Infections/PATHOLOGY/*PHYSIOPATHOLOGY Macrophages/PATHOLOGY
Oligodendroglia/PATHOLOGY Phagocytosis Rats Spinal Cord/PATHOLOGY
T-Lymphocytes MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).